What NUT benefits Prostate Cancer & Breast Cancer? plus your Heart or Diabetes?


Below Extracts taken from the above “A Walnut-Enriched Diet Reduces the Growth of LNCaP Human Prostate Cancer Xenografts in Nude Mice” article (http://informahealthcare.com/doi/pdf/10.3109/07357907.2013.800095).

“Walnuts improved biomarkers of prostate and vascular health

“A walnut-enriched diet markedly reduced the growth of subcutaneously-inoculated breast cancer cells and spontaneous tumor development in mice.  The obvious implication of these studies is that walnuts contain a specific phytochemical or a group of ingredients that act synergistically to suppress tumor initiation and growth.”

“While the walnut diet did not defer the onset of tumor initiation, it limited the number of mice that developed overt tumors as well as the growth rate and final size of the tumors.”

“Walnuts have a number of ingredients that could account for their ability to suppress prostate tumor growth”

“Most notably, walnuts contain high levels of omega-3 fatty acids; the elevated intake of long-chain [20c eicosapentaenoic acid (EPA) and 22c docosahexaenoic acid (DHA)] fats, in particular, slows cancer growth.  The walnut diet used in the current study, however, contained essentially no EPA or DHA.”

“The mouse liver has the capability of elongating and desaturating alpha-linolenic acid (ALA) to EPA and DHA, probably in small amounts.”

“Walnut consumption by rats in the initial study does not mean these increases were exclusively a result of the intake of melatonin, a potent antioxidant but could have been a consequence of any or all of the antioxidants mentioned earlier.

The seemingly most likely explanation for the finding that a walnut-enriched diet forestalled the growth of human prostate cancer cells growing in immune-compromised mice is that the inhibitory effect was a consequence of the combined actions of several phytochemicals in this nut which have been shown individually to inhibit experimental prostate cancer.  Which of these functioned synergistically to suppress prostate cancer cell growth could not be determined from this study.”

“Another publication appeared in which a similar walnut-enriched diet, like the one used here, also inhibited prostate cancer growth in mice.”

“Compared to a control diet lacking walnut, the experimental diet reduced the development of prostate adenocarcinoma in the TRAMP cancer model.”

“The measurement of hepatic F2-isoprostanes, a sensitive index of oxidative damage to cell membrane lipids also provided important information relative to the antioxidant capacity of walnuts.  The lower levels of lipid peroxidation products in the walnut-consuming mice indicated that the basal levels of lipid peroxidation were depressed by the walnut diet.  Clearly, the presence of a prostate tumor did not exaggerate the breakdown of hepatic lipids since the mice that consumed the control diet (lacking walnuts) all had elevated lipid peroxidation products in the hepatocytes whether or not the animal had developed a prostate tumor.”

“The intensity of the PSA immunoreactivity in the prostate cancers did not differ between the control and walnut diet fed mice.”

“The failure of PSA levels to be noticeably influenced by walnut consumption is consistent with two previous studies in humans in which circulating levels of PSA were not changed as a result of walnut consumption.

Further Reading:

Davis PA, Vasu VT, Gohil K, Kim H, Khan IH, Cross CE, Yokoyama W.   A high-fat diet containing whole walnuts (Juglans Regia) reduces tumor size and growth along with plasma insulin like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model.  Br J Nutr 2013; 108: 1764–1772.

Spaccarotella KJ, Kris-Etherton PM, Stone WL, Bagshaw DM, Fishell VK, West SG, Lawrence FR, Hartman TJ.   The effects of walnut intake on factors related to prostate and vascular health in older men. Nutr J 2008;1:13–22.

Simon JA, Tanzman JS, Sabate J.   Lack of effect of walnuts on serum levels of prostate specific antigen: a brief report. J Am Coll Nutr 2007;26:317–320.




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